Calc Function

    • Calcs that help predict probability of a diseaseDiagnosis
    • Subcategory of 'Diagnosis' designed to be very sensitiveRule Out
    • Disease is diagnosed: prognosticate to guide treatmentPrognosis
    • Numerical inputs and outputsFormula
    • Med treatment and moreTreatment
    • Suggested protocolsAlgorithm

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    Patent Pending

    Binet Staging System for Chronic Lymphocytic Leukemia (CLL)

    Stages chronic lymphocytic leukemia, similar to Rai Staging System.
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    When to Use

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    <3
    ≥3
    No
    Yes
    No
    Yes

    Result:

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    Next Steps
    Evidence
    Creator Insights

    Advice

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    Formula

    Selection of the appropriate features:

    Clinical features

    Binet Stage

    <3 areas of lymphadenopathy*, and normal hemoglobin and platelet count

    A

    ≥3 areas of lymphadenopathy*, and normal hemoglobin and platelet count

    B

    Anemia (Hgb <10 g/dL) and/or thrombocytopenia (platelets <100,000/mm³), regardless of number of areas of lymphadenopathy

    C

    *Nodal areas: cervical, axillary, inguinal (one side or both), spleen, and liver.

    Facts & Figures

    Interpretation:

    Binet Stage

    Risk group

    Overall survival

    A

    Low

    12 years

    B

    Intermediate

    7 years

    C

    High

    2-4 years

    From Nabhan 2014.

    Dr. Jacques-Louis Binet

    About the Creator

    Jacques-Louis Binet, MD, is a retired hematologist at the Hôpital de la Pitié-Salpétrière in Paris, France. During his time practicing medicine, he was also a professor of medicine at the Pierre and Marie-Curie University in Paris, France. Dr. Binet’s primary research was focused on immunology, blood transfusion, and leukemia.

    To view Dr. Jacques-Louis Binet's publications, visit PubMed

    About the Creator
    Dr. Jacques-Louis Binet