Cytokine Release Syndrome (CRS) Grading

Clinical judgment should be exercised at all times regarding the observed time course of symptoms and the patient's functional reserve. Tailoring interventions and moving to second-line agents, ruling out other causes, and follow-up are key.

• Monitoring and aggressive supportive care should be considered in order to prevent irreversible end-organ damage.

• Consider ICU setting (1:1 nursing care).

• Consider involving expert consultative services.

Always investigate for alternate causes such as infection, tumor lysis syndrome, or organ dysfunction. Always evaluate for end-organ damage.