MDCalc

DIPSS/DIPSS Plus (Dynamic International Prognostic Scoring System) for Myelofibrosis

Estimates survival in patients with primary myelofibrosis.

Be aware that this tool provides results for either DIPSS or DIPSS Plus, depending on whether karyotype information is available.

  • If karyotype is not available, the tool defaults to DIPSS. 
  • If karyotype information is input, the tool defaults to DIPSS Plus, which requires additional variables, such as transfusion dependency and platelet count.

Age >65 years

White blood cell count >25,000 /μL

Hemoglobin <10 g/dL

Peripheral blood blast ≥1%

Constitutional symptoms

Is karyotype information available?

Select 'Yes' to enable DIPSS plus score calculation with karyotype information

Result:

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Advice
  • Use results in conjunction with clinical judgment and patient preference to guide management care plans and inform goals of care discussions.
    • High and intermediate-2 risk: Consider more aggressive treatments, such as referral to a transplant center for allogeneic stem cell transplantation evaluation, particularly in younger patients with good functional status.
    • Intermediate-1 and low risk: Consider more conservative, symptom-directed treatment with regular follow-up.
  • Results are prognostic, not predictive of treatment response; clinical judgment and specialist consultation remain essential.
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