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    • Subcategory of 'Diagnosis' designed to be very sensitiveRule Out
    • Disease is diagnosed: prognosticate to guide treatmentPrognosis
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    Attention COACH STUDY participants:

    The principal investigators of the study request that you use the official version of the modified score here.

    NAFLD (Non-Alcoholic Fatty Liver Disease) Activity Score

    Diagnoses steatohepatitis, based on histology, in NAFLD patients.

    INSTRUCTIONS

    Use in patients who have had liver biopsy for NAFLD. The score should not be used as a surrogate for NASH diagnosis (see Brunt and Kleiner 2011 for details).

    When to Use

    Do you use the NAFLD Activity Score and want to contribute your expertise? Join our contributor team!

    <5%
    0
    5-33%
    +1
    34-66%
    +2
    >66%
    +3
    No foci
    0
    1 focus per 200× field
    +1
    2‐4 foci per 200× field
    +2
    >4 foci per 200× field
    +3
    None
    0
    Few balloon cells
    +1
    Many cells/prominent ballooning
    +2

    Result:

    Please fill out required fields.

    Next Steps
    Evidence
    Creator Insights
    Dr. David E. Kleiner

    About the Creator

    David E. Kleiner, MD, PhD, is an anatomical pathologist at the National Cancer Institute. He is also director of clinical operations and chief of the postmortem pathology section at the NIH. Dr. Kleiner’s research focuses primarily on chronic liver disease and transplantation pathology.

    To view Dr. David E. Kleiner's publications, visit PubMed

    About the Creator
    Dr. David E. Kleiner
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