Rome IV Diagnostic Criteria for Reflux Hypersensitivity
Use in patients with symptoms suggestive of reflux hypersensitivity, such as unexplained recurrent retrosternal symptoms (including heartburn and chest pain), for at least 6 months.
Patients with any of the following features must be evaluated clinically for other diagnoses even though functional heartburn may be present:
Symptoms suggestive of cardiac ischemia.
Unexplained iron deficiency anemia.
Unintentional weight loss.
Palpable cervical lymphadenopathy on exam.
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