MDCalc

North American Familial Chylomicronemia Score (NAFCS)

Facilitates familial chylomicronemia syndrome (FCS) diagnosis.

This score has several important disclaimers:

  • Derived by expert consensus using the RAND/UCLA modified Delphi panel method; the validation study examined a single lipid-clinic registry in Ontario.
  • No prospective, multi-centre, or ethnically diverse external validation data are available.
  • The study was conducted by ADVI, a research consultancy, under a contract funded by Ionis Pharmaceuticals; most authors report consulting fees/honoraria or research grants from multiple pharmaceutical companies (e.g., Ionis, Akcea, Regeneron, Novartis, Amgen, Pfizer, Sanofi).

Current age, years

BMI

History of pancreatitis

Presence of secondary factors that may contribute to HTG

See list of secondary factors here.

Laboratory Values

All >880 mg/dL

Ratio TG/ >8

When measured in mg/dL

<1.0 g/L

Result:

Please fill out required fields.
Advice
  • Use the results of this tool alongside clinical judgment and, where possible, lipid or genetics-specialist expertise; it should not be the sole determinant of diagnosis or management.
  • A high score is highly specific but not diagnostic.
  • Results may direct when to perform genetic testing (i.e., scores ≥30-44) and when to initiate FCS-specific therapy while awaiting genetic testing results (i.e., scores ≥60).
Have feedback about this calculator?