MDCalc

Mutation-Adjusted Risk Score (MARS)

Stratifies prognostic risk for adults with advanced systemic mastocytosis.

Age, years

Hemoglobin

Platelets

Presence of adverse mutations

(SRSF2, ASXL1, and/or RUNX1)

Result:

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Advice
  • Interpret results alongside the specific disease variant, clinical symptoms, extent of organ dysfunction, and mast cell burden when determining treatment strategies.
  • A higher score is associated with poorer prognosis, and these patients may be prioritized for more aggressive management.