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    Chief Complaint


    Organ System


    Patent Pending

    Urine Anion Gap

    Detects urine acidosis for evaluation of non-gap metabolic acidosis.
    When to Use
    Why Use
    • The patient with an unexplained non-gap metabolic acidosis.
    • The patient with a mixed metabolic acidosis.
    • Evaluation for suspected RTA.

    This simple urine test can help differentiate the causes of a non-gap metabolic acidosis (HARDUP):

    • Hyperchloremia
    • Acetazolamide, Addison’s disease
    • Renal tubular acidosis
    • Diarrhea, vomiting, ileostomies, fistulae
    • Ureteroenteric fistulae
    • Pancreatoduodenal fistulae


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    Next Steps
    Creator Insights
    Dr. Marc Goldstein

    About the Creator

    Marc Goldstein, MD, DSc (hon), FACS is a professor of reproductive medicine and urology at Weill Cornell Medical College of Cornell University. He is also surgeon-in-chief of male reproductive medicine and surgery and the director of the Center for Male Reproductive Medicine and Microsurgery at the New York Presbyterian Hospital Weill Cornell Medical Center. Dr. Goldstein is a senior scientist with the Population Council’s Center for Biomedical Research and has published over 290 journal articles and book chapters.

    To view Dr. Marc Goldstein's publications, visit PubMed

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    MDCalc loves calculator creators – researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients.
    About the Creator
    Dr. Marc Goldstein
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