Calc Function

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    Chief Complaint


    Organ System


    Patent Pending

    UCLA Integrated Staging System (UISS) for Renal Cell Carcinoma (RCC)

    Provides 5-year disease-free prognosis for localized and metastatic RCC.


    When to Use
    Why Use

    Patients with RCC, localized or metastatic, particularly those being considered for clinical trial enrollment.

    • This score placed patients with local or metastatic renal cell carcinoma (mRCC) into mortality risk groups: low, intermediate/moderate, and high.
    • The derivation and numerous external validations have been chart reviews, though all find orderly progressions in 5-year survival based on group.
    • Prospective validation is eagerly awaited, and we know of no validations including substantial numbers of patients treated with modern targeted VEGF therapy.

    There are no validated scoring systems for predicting survival in mRCC. Using a score may help sketch categories of survival time better than clinical judgment alone.



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    Next Steps
    Creator Insights
    Dr. Amnon Zisman

    About the Creator

    Amnon Zisman, MD, is professor of urologic surgery at Sackler School of Medicine affiliated Tel Aviv University. He is currently head of urology department at Assaf Harofeh Medical Center. Dr. Zisman’s research focuses on increased accuracy of diagnosis and prognosis of RCC as well as novel treatment strategies in renal disease.

    To view Dr. Amnon Zisman's publications, visit PubMed

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    MDCalc loves calculator creators – researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients.
    About the Creator
    Dr. Amnon Zisman
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