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    Chief Complaint


    Organ System


    Patent Pending

    HOMA-IR (Homeostatic Model Assessment for Insulin Resistance)

    Approximates insulin resistance.
    When to Use
    Why Use

    Patients evaluated for potentially impaired glucose tolerance and diabetes.

    The score, a shortcut for estimating insulin resistance (IR), has been examined in multiple studies. Results typically show reasonable correlation between HOMA-IR and ‘clamp’ measurement, the gold standard. However, agreement levels between the two, a more important gauge for individual accuracy and clinical use, are weak, suggesting more research and refinement are needed for clinical use.

    Clamp methods for measuring IR are resource intensive, invasive, and time consuming, and IR can be a useful metric. An estimate of IR may help decision making.



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    Creator Insights
    Dr. David R. Matthews

    About the Creator

    David R. Matthews, MD, is a Professor of Diabetic Medicine at the University of Oxford. He is the Deputy co-ordinator and member of the Executive and Policy Advisory Committees of the UK Prospective Study of Diabetes (UKPDS), as well as the founder of the Oxford Health Alliance. He is currently investigating the inter-relationships between insulin resistance and beta cell function, and the effects of a low carbohydrate diet in people with and without type 2 diabetes at Churchill Hospital with the Center of Diabetes, in the United Kingdom.

    To view Dr. David R. Matthews's publications, visit PubMed

    Are you Dr. David R. Matthews? Send us a message to review your photo and bio, and find out how to submit Creator Insights!
    MDCalc loves calculator creators – researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients.
    About the Creator
    Dr. David R. Matthews
    Are you Dr. David R. Matthews?