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    Patent Pending

    Simon Broome Diagnostic Criteria for Familial Hypercholesterolemia (FH)

    Diagnoses familial hypercholesterolemia (FH) based on clinical, genetic and family history.
    When to Use
    Pearls/Pitfalls
    Why Use

    Patients suspected to have familial hypercholesterolemia (FH) by clinical and laboratory features.

    • The Simon Broome Diagnostic Criteria for FH are the most widely used criteria for diagnosing FH in the UK.
    • Stratifies likelihood into one of three categories: definite, probable, and unlikely.
    • May have limited validity in non-British populations.
    • Requires DNA testing for complete data.
    • Patients with FH are at increased risk for coronary heart disease, yet many patients remain undiagnosed.
    • NICE guidelines for FH recommend using the Simon Broome criteria for diagnosis of FH in the UK.
    • Other accepted criteria for diagnosis of FH include the US MEDPED Criteria and the Dutch Criteria. The risk factors in each criteria set are similar, and clinical judgment as well as local practice factors (similarity of target population to study population) should be considered.
    <16
    ≥16
    mg/dL
    mg/dL
    No
    0
    Yes
    +1
    No
    0
    Yes
    +1
    No
    0
    Yes
    +1
    No
    0
    Yes
    +1

    Result:

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    Next Steps
    Evidence
    Creator Insights
    Dr. John Betteridge

    About the Creator

    John Betteridge, BSc, MB BS, PhD, MD, FRCP, FAHA, is a practicing endocrinologist at University College London. He is a past chairman of HEART UK and past president of the Council on Lipids in Clinical Medicine at The Royal Society of Medicine. Prof Betteridge is an active researcher with over 300 publications in peer-reviewed journals, with a focus in diabetes and lipid management.

    To view Dr. John Betteridge's publications, visit PubMed

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    MDCalc loves calculator creators – researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients.
    About the Creator
    Dr. John Betteridge
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