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    Patent Pending

    Metroticket Calculator for Hepatocellular Carcinoma (HCC) Survival

    Predicts survival for patients with HCC.
    When to Use
    Why Use
    • Derived in order to explore whether certain patients not fulfilling Milan Criteria could potentially benefit from liver transplant.
    • Similar survival as Milan criteria if criteria are expanded to Up-to-Seven(size of largest tumor in cm + number of tumors ≥7).
    • Not as widely used or validated as the original Milan criteria.
    • Tumor grade was not included as a prognostic factor, though it is known to correlate with survival. The authors cited a high number of patients missing data on tumor grade (28.5%) and used vascular invasion as an alternate pathologic parameter. 
    • Patients with HCC not fulfilling Milan Criteria but who may be considered for transplant with similar benefit.
    • Allows patients who don't fit the original Milan Criteria to be considered for transplantation with similar predicted survival benefit.
    • Offers potential curative option for patients who don't meet the Milan criteria.


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    Creator Insights
    Dr. Vincenzo Mazzaferro

    About the Creator

    Vincenzo Mazzaferro, MD, is a professor of medicine and director of the Gastrointestinal and Hepato-Pancreatic Surgery and Liver Transplantation Unit at the Istituto Nazionale dei Tumori in Milan, Italy. He is an avid researcher of liver transplantation and studies treatment of metastatic cancers to the liver and novel treatments of tumors. Dr. Mazzaferro’s research group was responsible for the development of the Milan Criteria, which has been adopted as a transplant guideline in many countries.

    To view Dr. Vincenzo Mazzaferro's publications, visit PubMed

    Are you Dr. Vincenzo Mazzaferro? Send us a message to review your photo and bio, and find out how to submit Creator Insights!
    MDCalc loves calculator creators – researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients.
    About the Creator
    Dr. Vincenzo Mazzaferro
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