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    Chief Complaint


    Organ System


    Patent Pending

    EUTOS Score for Chronic Myelogenous Leukemia (CML)

    Predicts outcomes after CML treatments, specifically adjusted for tyrosine kinase treatments.


    Use in newly-diagnosed patients before starting therapy.

    When to Use
    Why Use

    Newly-diagnosed CML patients prior to discussions regarding prognosis and treatment options.

    • The EUTOS (European Treatment and Outcome Study) Score predicts survival and can also be used to predict the probability of complete cytogenetic response at 18 months.
    • Has better predictive value than the Sokal Score.
    • Spleen size estimation is subjective; however, that subjectivity is also included in other CML prognostic scores.
    • Developed in patients treated with imatinib, so outcomes may not apply with newer generation therapies.
    • Estimates response to therapy to, and survival on, the reference TKI (tyrosine kinase inhibitor) imatinib.
    • Only requires two values, which can be clinically detected prior to completing a bone marrow biopsy.


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    Creator Insights
    Dr. Joerg Hasford

    About the Creator

    Joerg Hasford, MD, PhD, is a Professor of Medical Data Processing, Biometrics and Epidemiology at the University of Munich in Germany. He is the chairman of the Ethics Committee of the Bavarian Medical Association and the Working Group Medical Ethics Commissions in the Federal Republic of Germany. In 2000, he was awarded the Paul Martini Prize of the German Society of Medical computer science, Biometry and Epidemiology, Dr. Hasford has also published numerous articles and serves as an editor for Pharmacoepidemiology and Drug Safety publication.

    To view Dr. Joerg Hasford's publications, visit PubMed

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    MDCalc loves calculator creators – researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients.
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