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      Calc Function

    • Calcs that help predict probability of a diseaseDiagnosis
    • Subcategory of 'Diagnosis' designed to be very sensitiveRule Out
    • Disease is diagnosed: prognosticate to guide treatmentPrognosis
    • Numerical inputs and outputsFormula
    • Med treatment and moreTreatment
    • Suggested protocolsAlgorithm





    Chief Complaint


    Organ System


    Patent Pending

    Transtubular Potassium Gradient (TTKG)

    May help in assessment of hyperkalemia or hypokalemia.
    When to Use

    Patients with hyper- or hypokalemia (defined as K+ <3.5 or >5.0 mEq/L in this calculator).

    TTKG is sometimes criticized for being inaccurate, particularly in the evaluation of hyperkalemia. 



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    Creator Insights
    Dr. Mitchell L. Halperin

    About the Creator

    Mitchell L. Halperin, MD, is a professor of medicine at University of Toronto. He is also an attending physician at St. Michael’s Hospital in Toronto, Canada. Dr. Halperin’s primary research is focused on renal physiology, acid base homeostasis, and metabolic regulation.

    To view Dr. Mitchell L. Halperin's publications, visit PubMed

    Are you Dr. Mitchell L. Halperin? Send us a message to review your photo and bio, and find out how to submit Creator Insights!
    MDCalc loves calculator creators – researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients.
    About the Creator
    Dr. Mitchell L. Halperin
    Are you Dr. Mitchell L. Halperin?