Calc Function

  • Diagnosis
  • Rule Out
  • Prognosis
  • Formula
  • Treatment
  • Algorithm
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    Evidence-Based Approach to the Diagnosis and Management of Esophageal Eosinophilia and Eosinophilic Esophagitis (EoE)

    Official guideline from the American College of Gastroenterology.

    summary by Sarina Lowe, MD Shannon Chang, MD

    Diagnosis

    Definitions and Criteria

    Strong recommendation
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    Moderate quality evidence

    Strong recommendation
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    Low quality evidence

    Strong recommendation
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    Low quality evidence

    Strong recommendation
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    Low quality evidence

    PPI-responsive Esophageal Eosinophilia (PPI-REE) and GERD

    Conditional recommendation
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    Low quality evidence

    Strong recommendation
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    Low quality evidence

    Conditional recommendation
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    Low quality evidence

    Treatment

    Endpoints

    Conditional recommendation
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    Low quality evidence

    Conditional recommendation
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    Moderate quality evidence

    Pharmacologic

    Strong recommendation
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    High quality evidence

    Conditional recommendation
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    Low quality evidence

    Conditional recommendation
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    Low quality evidence

    Dietary

    Strong recommendation
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    Moderate quality evidence

    Conditional recommendation
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    Moderate quality evidence

    Conditional recommendation
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    Low quality evidence

    Conditional recommendation
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    Low quality evidence

    Endoscopic

    Conditional recommendation
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    Moderate quality evidence

    Conditional recommendation
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    Moderate quality evidence

    Outcomes

    Natural History

    Strong recommendation
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    Moderate quality evidence

    Maintenance

    Strong recommendation
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    Moderate quality evidence

    Conditional recommendation
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    Low quality evidence

    How strong is the ACG's recommendation?

    Strong recommendation
    Intervention's desirable effects clearly outweigh undesirable effects.
    Moderate recommendation
    Further research likely to impact confidence in estimate of effect.
    Conditional recommendation
    Uncertainty in tradeoffs between desirable & undesirable effects of intervention.
    Uncertainty in tradeoffs between desirable & undesirable effects of intervention.
    High quality evidence
    Further research unlikely to change guideline authors' confidence in estimate of effect.
    Between high and moderate levels of evidence.
    Moderate quality evidence
    Further research likely to impact confidence in estimate of effect.
    Low quality evidence
    Further research expected to have important impact in confidence in estimate of effect.
    Very low quality evidence
    Effect is very uncertain.