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      Calc Function

    • Calcs that help predict probability of a diseaseDiagnosis
    • Subcategory of 'Diagnosis' designed to be very sensitiveRule Out
    • Disease is diagnosed: prognosticate to guide treatmentPrognosis
    • Numerical inputs and outputsFormula
    • Med treatment and moreTreatment
    • Suggested protocolsAlgorithm





    Chief Complaint


    Organ System


    Patent Pending

    Modified Glasgow Prognostic Score (mGPS) for Cancer Outcomes

    Provides improved cancer prognosis over the original score, based on serum biomarkers.


    We recommend this modified version of the score over the original GPS.
    When to Use
    Why Use

    Patients with known cancer.

    • The Modified Glasgow Prognostic Score (mGPS) has been evaluated across numerous different cancer cohorts and suggests incrementally worsening prognosis with increasing score.
    • Depending upon patient selection, stage, cancer and other factors the resulting survival numbers vary widely.
    • The modified GPS uses the same parameters as the original GPS (CRP and albumin), but weighs the inflammatory component more heavily; i.e., patients with low albumin are still assigned a score of 0 even if CRP is elevated. This modification was shown to have better correlation with survival (in colon and rectal cancer from the original paper, and in other cancers from the validation papers).

    Multiple studies suggest significantly worse outcome in multiple types of cancer, including “increased weight loss, poor performance status, increased comorbidity, increased pro-inflammatory and angiogenic cytokines and complications on treatment.” (McMillan DC 2013)

    CRP ≤10 mg/L
    CRP >10 mg/L
    Albumin <3.5 g/dL (35 g/L)
    Albumin ≥3.5 g/dL (35 g/L)


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    Next Steps
    Creator Insights


    The Modified Glasgow Prognosis Score helps stratify prognosis groups and may be a worthy addition to multifactorial evaluations. As a stand-alone in individual cases it is unclear at this point how accurate it is likely to be.


    We are unaware of validated management algorithms using the mGPS.

    Critical Actions

    The modified GPS does not assign a point for low albumin as a singular finding, which is different from the original GPS. The c-reactive protein value must be elevated for points to be assigned.

    About the Creator
    Dr. Donald McMillan
    Dr. Michael J. Proctor
    Are you Dr. Michael J. Proctor?