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      Calc Function

    • Calcs that help predict probability of a diseaseDiagnosis
    • Subcategory of 'Diagnosis' designed to be very sensitiveRule Out
    • Disease is diagnosed: prognosticate to guide treatmentPrognosis
    • Numerical inputs and outputsFormula
    • Med treatment and moreTreatment
    • Suggested protocolsAlgorithm

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    Patent Pending

    Modified Glasgow Prognostic Score (mGPS) for Cancer Outcomes

    Provides improved cancer prognosis over the original score, based on serum biomarkers.

    INSTRUCTIONS

    We recommend this modified version of the score over the original GPS.
    When to Use
    Pearls/Pitfalls
    Why Use

    Patients with known cancer.

    • The Modified Glasgow Prognostic Score (mGPS) has been evaluated across numerous different cancer cohorts and suggests incrementally worsening prognosis with increasing score.
    • Depending upon patient selection, stage, cancer and other factors the resulting survival numbers vary widely.
    • The modified GPS uses the same parameters as the original GPS (CRP and albumin), but weighs the inflammatory component more heavily; i.e., patients with low albumin are still assigned a score of 0 even if CRP is elevated. This modification was shown to have better correlation with survival (in colon and rectal cancer from the original paper, and in other cancers from the validation papers).

    Multiple studies suggest significantly worse outcome in multiple types of cancer, including “increased weight loss, poor performance status, increased comorbidity, increased pro-inflammatory and angiogenic cytokines and complications on treatment.” (McMillan DC 2013)

    CRP ≤10 mg/L
    CRP >10 mg/L
    Albumin <3.5 g/dL (35 g/L)
    Albumin ≥3.5 g/dL (35 g/L)

    Result:

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    Next Steps
    Evidence
    Creator Insights
    Dr. Donald McMillan

    About the Creator

    Donald McMillan, MD, is a professor of surgical science at the University of Glasgow and an associate academic at the Institute of Cancer Sciences. His research focuses on systemic inflammatory response in weight loss and poor physical function, quality of life and survival of cancer patients.

    To view Dr. Donald McMillan's publications, visit PubMed

    Dr. Michael J. Proctor

    About the Creator

    Michael J. Proctor, MD, is a faculty member at the University of Glasgow and practices at the Royal Infirmary. His research focuses on systemic inflammatory response in weight loss, poor physical function and quality of life and poor survival of the patient with cancer.

    To view Dr. Michael J. Proctor's publications, visit PubMed

    Are you Dr. Michael J. Proctor? Send us a message to review your photo and bio, and find out how to submit Creator Insights!
    MDCalc loves calculator creators – researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients.
    About the Creator
    Dr. Donald McMillan
    Dr. Michael J. Proctor
    Are you Dr. Michael J. Proctor?