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      Calc Function

    • Calcs that help predict probability of a diseaseDiagnosis
    • Subcategory of 'Diagnosis' designed to be very sensitiveRule Out
    • Disease is diagnosed: prognosticate to guide treatmentPrognosis
    • Numerical inputs and outputsFormula
    • Med treatment and moreTreatment
    • Suggested protocolsAlgorithm

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    Patent Pending

    Radiation Biologically Effective Dose (BED) Calculator

    Calculates biologically effective dose (BED) and equivalent dose (EQD2) for cancer radiotherapy.
    When to Use
    Pearls/Pitfalls
    Why Use

    Patients undergoing radiation (to compare different fractionation regimens).

    • Note that BED is the biologically effective dose, not biologically equivalent dose.

    • EQD2 is the equivalent dose in 2-Gy fractions.

    • An α/β ratio of 10 is typically used for early-responding tissues and tumors.

    • An α/β ratio of 3 is typically used for late-responding tissues, such as normal tissue.

    • Prostate cancer has a low α/β ratio of ~1.5.

    Compares different fractionation regimens with hypofractionation or stereotactic body radiation therapy (SBRT) using a common numerical score.

    Gy
    Gy

    Result:

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    Next Steps
    Evidence
    Creator Insights
    Dr. John F. Fowler

    About the Creator

    John F. Fowler, DSc, PhD, FInsTP, (d. 2016) was the director of the Gray Laboratory at Mount Vernon Hospital in England, UK. He also served as president of the Hospital Physicists Association, European Society of Radiation Biology, and the British Institute of Radiology. Dr. Fowler’s primary research was focused on dose fractionation and tumor control.

    To view Dr. John F. Fowler's publications, visit PubMed

    Are you Dr. John F. Fowler? Send us a message to review your photo and bio, and find out how to submit Creator Insights!
    MDCalc loves calculator creators – researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients.
    Content Contributors
    • Neil Panjwani, MD
    Reviewed By
    • Hilary Bagshaw, MD
    About the Creator
    Dr. John F. Fowler
    Are you Dr. John F. Fowler?
    Content Contributors
    • Neil Panjwani, MD
    Reviewed By
    • Hilary Bagshaw, MD