Calc Function

    • Calcs that help predict probability of a diseaseDiagnosis
    • Subcategory of 'Diagnosis' designed to be very sensitiveRule Out
    • Disease is diagnosed: prognosticate to guide treatmentPrognosis
    • Numerical inputs and outputsFormula
    • Med treatment and moreTreatment
    • Suggested protocolsAlgorithm

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    Patent Pending

    Simplified Autoimmune Hepatitis (AIH) Score

    Diagnoses autoimmune hepatitis.
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    INSTRUCTIONS

    Use in patients with histological evidence of hepatitis. Do not use in patients with normal histology.

    When to Use
    Pearls/Pitfalls
    Why Use

    Patients with established hepatitis and available liver biopsy results, but unclear diagnosis.

    The Simplified Autoimmune Hepatitis (AIH) Score was developed to simplify AIH diagnosis and reduce false positive diagnoses.

    AIH is multifactorial, complex, and typically has many competing diagnoses. The score offers a data driven, consensus-based path to help guide treatment and is likely to be better than clinical judgment alone.

    <1:40
    ≥1:40
    ≥1:80
    <1:40
    ≥1:40
    Negative
    Positive
    Normal
    0
    ≥Upper limit of normal
    +1
    ≥1.1× upper limit of normal
    +2
    Compatible with AIH
    +1
    Typical of AIH
    +2
    Present
    0
    Absent
    +2

    Result:

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    Next Steps
    Evidence
    Creator Insights

    Advice

    AIH is a complex diagnosis partly because there is no anatomic criterion (i.e. ‘gold’) standard. AIH scoring neatly solves this problem by defining the diagnosis. ‘Likely’ scores appear highly reliable.

    Management

    We are unaware of validated management algorithms using the AIH scores.

    Critical Actions

    Overlap with multiple hepatic conditions is always a concern to consider despite score findings, and ‘likely’ scores are more predictive than ‘probable’ ones.

    About the Creator
    Dr. Ansgar W. Lohse