NINCDS-ADRDA Criteria for Alzheimer’s Disease
Diagnoses Alzheimer disease (AD), alternative to IWG-2 Criteria.
Advice
- Always exclude reversible causes of cognitive decline (e.g., vitamin B12 deficiency, hypothyroidism, structural brain pathology).
- Consider supplementing these criteria with modern diagnostic tools.
- If the criteria support an AD diagnosis, consider:
- Tailoring treatment based on disease stage and symptom severity, considering cholinesterase inhibitors, memantine, or newly available therapies as appropriate.
- Reinforcing non-pharmacologic interventions (e.g., exercise, cognitive training, social engagement).
- Offering caregiver support resources and discussing advanced care planning.
- Monitoring disease progression and reassessing treatment plans periodically.
- For complex cases or those requiring advanced imaging or biomarkers, consider referral to neurology or geriatric psychiatry.