Corrected Count Increment (CCI) for Platelet Transfusion
Assesses adequacy of response to platelet transfusion.
Advice
- When no compatible platelets can be found to transfuse to a patient with platelet refractoriness, alternative measures can be tried to stem or forestall hemorrhage, but these are of unpredictable benefit.
- Administration of antifibrinolytic agents, such as ε-aminocaproic acid (Amicar), either intravenously or, in the case of gingival bleeding, as a mouthwash, may allow the clot that is formed to be sustained.
- Consider baseline patient factors, including age, gender, height/weight, history of pregnancy, and previous transfusion.
- Possible patient characteristics to be evaluated for each transfusion:
- Administration of amphotericin, heparin, or γ-globulin.
- HLA and/or PLT antibody status of the closest sample prior to the transfusion.
- Presence of bleeding, fever, infection, transfusion reaction, splenomegaly.